{"id":6119,"date":"2021-08-16T11:39:02","date_gmt":"2021-08-16T14:39:02","guid":{"rendered":"https:\/\/cgceducacao.com.br\/?p=6119"},"modified":"2021-08-16T11:43:06","modified_gmt":"2021-08-16T14:43:06","slug":"brazilian-study-is-featured-in-a-special-collection-of-articles-in-the-journal-of-experimental-medicine","status":"publish","type":"post","link":"https:\/\/cgceducacao.com.br\/index.php\/2021\/08\/16\/brazilian-study-is-featured-in-a-special-collection-of-articles-in-the-journal-of-experimental-medicine\/","title":{"rendered":"Brazilian study is featured in a special collection of articles in the \u201cJournal of Experimental Medicine\u201d"},"content":{"rendered":"<p> The study shows that a mechanism known as a neutrophil extracellular trap is involved in the exacerbated inflammatory response of COVID, paving the way to new therapeutic approaches<\/p>\n<div class=\"heateorSssClear\"><\/div>\n<div class=\"heateor_sss_sharing_container heateor_sss_horizontal_sharing\">\n<div class=\"heateor_sss_sharing_title\" style=\"font-weight:bold\"><\/div>\n<ul class=\"heateor_sss_sharing_ul\">\n<li class=\"heateorSssSharingRound\"><i style=\"width:30px;height:30px;border-radius:5px\" title=\"Facebook\" class=\"heateorSssSharing heateorSssFacebookBackground\"><\/i><\/li>\n<li class=\"heateorSssSharingRound\"><i style=\"width:30px;height:30px;border-radius:5px\" title=\"Whatsapp\" class=\"heateorSssSharing heateorSssWhatsappBackground\"><\/i><\/li>\n<li class=\"heateorSssSharingRound\"><i style=\"width:30px;height:30px;border-radius:5px\" title=\"Twitter\" class=\"heateorSssSharing heateorSssTwitterBackground\"><\/i><\/li>\n<li class=\"heateorSssSharingRound\"><i style=\"width:30px;height:30px;border-radius:5px\" title=\"Linkedin\" class=\"heateorSssSharing heateorSssLinkedinBackground\"><\/i><\/li>\n<li style=\"padding:6.3px 0 !important\" class=\"heateor_sss_facebook_like\">\n<div class=\"fb-like\" data-href=\"https:\/\/www5.usp.br\/news\/brazilian-study-is-featured-in-a-special-collection-of-articles-in-the-journal-of-experimental-medicine\/\" data-layout=\"button\" data-action=\"like\" data-show-faces=\"false\" data-share=\"false\"><\/div>\n<\/li>\n<\/ul>\n<div class=\"heateorSssClear\"><\/div>\n<\/div>\n<div class=\"heateorSssClear\"><\/div>\n<p><strong>By Ag\u00eancia FAPESP<\/strong><\/p>\n<figure id=\"attachment_210551\" aria-describedby=\"caption-attachment-210551\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-210551 size-full\" src=\"https:\/\/cgceducacao.com.br\/wp-content\/uploads\/2021\/08\/20210514_destaque_net.png\" alt width=\"1200\" height=\"630\" \/><figcaption id=\"caption-attachment-210551\" class=\"wp-caption-text\">Image of the NET being released by the neutrophil obtained by confocal microscopy \u2013 Photo: CRID\/USP<\/figcaption><\/figure>\n<p>In celebration of its 125th anniversary, the Journal of Experimental Medicine released a <a href=\"https:\/\/rupress.org\/jem\/collection\/19938\/JEM-Immunology-Collection-2021?fbclid=IwAR16jWZuI0mCyVLAA9oMzqYGP00LMgPo82A9RAWb9SEFIPFNwMtGNe0iCiM\">special collection<\/a> of recently published articles with some of the most relevant advances in the field of immunology.<\/p>\n<p>As the cover feature, the journal chose a Brazilian study developed at the <a href=\"https:\/\/bv.fapesp.br\/pt\/auxilios\/58581\/cpdi-centro-de-pesquisa-em-doencas-inflamatorias\/\">Center for Research on Inflammatory Diseases<\/a> <a href=\"http:\/\/http\/\/crid.fmrp.usp.br\/\">(CRID)<\/a>, a Center for Research, Innovation, and Diffusion (CEPID) of the S\u00e3o Paulo Research Foundation (FAPESP) based on the USP Ribeir\u00e3o Preto Medical School (FMRP).<\/p>\n<p>In the article, entitled <a href=\"https:\/\/rupress.org\/jem\/article\/217\/12\/e20201129\/152086\/SARS-CoV-2-triggered-neutrophil-extracellular?searchresult=1\">SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology<\/a>, the group led by professor <a href=\"https:\/\/bv.fapesp.br\/pt\/pesquisador\/31389\/fernando-de-queiroz-cunha\">Fernando de Queiroz Cunha<\/a> showed that an immunological mechanism known as a neutrophil extracellular trap (NET) is involved in the exacerbated inflammatory response that affects patients with the severe form of COVID-19. The discovery paves the way to new therapeutic approaches, including the repositioning of a drug used nowadays against cystic fibrosis (read more at: <a href=\"https:\/\/agencia.fapesp.br\/33435\/\">agencia.fapesp.br\/33435\/<\/a>).<\/p>\n<p>The article was also included in another special collection released by the journal entitled <a href=\"https:\/\/rupress.org\/jem\/collection\/18686\/COVID-19-from-basic-science-to-therapeutics\">\u201cCOVID-19: from basic science to therapeutics<\/a>\u201c, which gathers the latest discoveries about the physiopathology of COVID-19, therapeutic targets, and neutralizing antibodies.<\/p>\n<p>\u201cThe fact that our work is featured in two different fascicles of a highly reputable journal in the biomedical field is an unequivocal demonstration of the quality of the science that we do at the Ribeir\u00e3o Preto campus of USP \u2013 in particular at the CRID, which is funded by FAPESP. The quality of the work is a consequence of the scientific competence associated with the dedication of all members of the task force involved in investigating the immunopathology of COVID-19 at FMRP-USP\u201d, states Cunha.<\/p>\n<p>The collection dedicated to COVID-19 also brings another study developed by scientists connected to the CRID: <a href=\"https:\/\/rupress.org\/jem\/article\/218\/3\/e20201707\/211560\/Inflammasomes-are-activated-in-response-to-SARS?searchresult=1\">Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients<\/a>.<\/p>\n<p>The work, led by professor <a href=\"https:\/\/bv.fapesp.br\/pt\/pesquisador\/2858\/dario-simoes-zamboni\">Dario Zamboni<\/a>, describes the participation of an immunological mechanism known as inflammasome in the activation of the inflammatory process, which may cause damage to various organs and even lead to death patients with the severe form of COVID-19 (read more at: <a href=\"https:\/\/agencia.fapesp.br\/34680\/\">agencia.fapesp.br\/34680\/<\/a>).<\/p>\n<p>This text was originally published by <a href=\"https:\/\/agencia.fapesp.br\/\">Ag\u00eancia FAPESP<\/a> according to <a href=\"https:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/\">Creative Commons license CC-BY-NC-ND<\/a>. Read <a href=\"https:\/\/agencia.fapesp.br\/estudo-brasileiro-e-destaque-em-colecao-especial-de-artigos-do-ijournal-of-experimental-medicine-i\/35869\/\">the original here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The study shows that a mechanism known as a neutrophil extracellular trap is involved in the exacerbated inflammatory response of COVID, paving the way to new therapeutic approachesBy Ag\u00eancia FAPESPImage of the NET being released by the neutrophil obtained by confocal microscopy \u2013 Photo: CRID\/USPIn celebration of its 125th anniversary, the Journal of Experimental Medicine released a special collection of recently published articles with some of the most relevant advances in the field of immunology.As the cover feature, the journal chose a Brazilian study developed at the Center for Research on Inflammatory Diseases (CRID), a Center for Research, Innovation, and Diffusion (CEPID) of the S\u00e3o Paulo Research Foundation (FAPESP) based on the USP Ribeir\u00e3o Preto Medical School (FMRP).In the article, entitled SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology, the group led by professor Fernando de Queiroz Cunha showed that an immunological mechanism known as a neutrophil extracellular trap (NET) is involved in the exacerbated inflammatory response that affects patients with the severe form of COVID-19. The discovery paves the way to new therapeutic approaches, including the repositioning of a drug used nowadays against cystic fibrosis (read more at: agencia.fapesp.br\/33435\/).The article was also included in another special collection released by the journal entitled \u201cCOVID-19: from basic science to therapeutics\u201c, which gathers the latest discoveries about the physiopathology of COVID-19, therapeutic targets, and neutralizing antibodies.\u201cThe fact that our work is featured in two different fascicles of a highly reputable journal in the biomedical field is an unequivocal demonstration of the quality of the science that we do at the Ribeir\u00e3o Preto campus of USP \u2013 in particular at the CRID, which is funded by FAPESP. The quality of the work is a consequence of the scientific competence associated with the dedication of all members of the task force involved in investigating the immunopathology of COVID-19 at FMRP-USP\u201d, states Cunha.The collection dedicated to COVID-19 also brings another study developed by scientists connected to the CRID: Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.The work, led by professor Dario Zamboni, describes the participation of an immunological mechanism known as inflammasome in the activation of the inflammatory process, which may cause damage to various organs and even lead to death patients with the severe form of COVID-19 (read more at: agencia.fapesp.br\/34680\/).This text was originally published by Ag\u00eancia FAPESP according to Creative Commons license CC-BY-NC-ND. Read the original here.<\/p>\n","protected":false},"author":1,"featured_media":6121,"comment_status":"close","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59],"tags":[],"class_list":["post-6119","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fonte-da-educacao"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Brazilian study is featured in a special collection of articles in the \u201cJournal of Experimental Medicine\u201d - CGC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www5.usp.br\/news\/brazilian-study-is-featured-in-a-special-collection-of-articles-in-the-journal-of-experimental-medicine\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Brazilian study is featured in a special collection of articles in the \u201cJournal of Experimental Medicine\u201d - CGC\" \/>\n<meta property=\"og:description\" content=\"The study shows that a mechanism known as a neutrophil extracellular trap is involved in the exacerbated inflammatory response of COVID, paving the way to new therapeutic approachesBy Ag\u00eancia FAPESPImage of the NET being released by the neutrophil obtained by confocal microscopy \u2013 Photo: CRID\/USPIn celebration of its 125th anniversary, the Journal of Experimental Medicine released a special collection of recently published articles with some of the most relevant advances in the field of immunology.As the cover feature, the journal chose a Brazilian study developed at the Center for Research on Inflammatory Diseases (CRID), a Center for Research, Innovation, and Diffusion (CEPID) of the S\u00e3o Paulo Research Foundation (FAPESP) based on the USP Ribeir\u00e3o Preto Medical School (FMRP).In the article, entitled SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology, the group led by professor Fernando de Queiroz Cunha showed that an immunological mechanism known as a neutrophil extracellular trap (NET) is involved in the exacerbated inflammatory response that affects patients with the severe form of COVID-19. The discovery paves the way to new therapeutic approaches, including the repositioning of a drug used nowadays against cystic fibrosis (read more at: agencia.fapesp.br\/33435\/).The article was also included in another special collection released by the journal entitled \u201cCOVID-19: from basic science to therapeutics\u201c, which gathers the latest discoveries about the physiopathology of COVID-19, therapeutic targets, and neutralizing antibodies.\u201cThe fact that our work is featured in two different fascicles of a highly reputable journal in the biomedical field is an unequivocal demonstration of the quality of the science that we do at the Ribeir\u00e3o Preto campus of USP \u2013 in particular at the CRID, which is funded by FAPESP. The quality of the work is a consequence of the scientific competence associated with the dedication of all members of the task force involved in investigating the immunopathology of COVID-19 at FMRP-USP\u201d, states Cunha.The collection dedicated to COVID-19 also brings another study developed by scientists connected to the CRID: Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.The work, led by professor Dario Zamboni, describes the participation of an immunological mechanism known as inflammasome in the activation of the inflammatory process, which may cause damage to various organs and even lead to death patients with the severe form of COVID-19 (read more at: agencia.fapesp.br\/34680\/).This text was originally published by Ag\u00eancia FAPESP according to Creative Commons license CC-BY-NC-ND. 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CGC","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www5.usp.br\/news\/brazilian-study-is-featured-in-a-special-collection-of-articles-in-the-journal-of-experimental-medicine\/","og_locale":"pt_BR","og_type":"article","og_title":"Brazilian study is featured in a special collection of articles in the \u201cJournal of Experimental Medicine\u201d - CGC","og_description":"The study shows that a mechanism known as a neutrophil extracellular trap is involved in the exacerbated inflammatory response of COVID, paving the way to new therapeutic approachesBy Ag\u00eancia FAPESPImage of the NET being released by the neutrophil obtained by confocal microscopy \u2013 Photo: CRID\/USPIn celebration of its 125th anniversary, the Journal of Experimental Medicine released a special collection of recently published articles with some of the most relevant advances in the field of immunology.As the cover feature, the journal chose a Brazilian study developed at the Center for Research on Inflammatory Diseases (CRID), a Center for Research, Innovation, and Diffusion (CEPID) of the S\u00e3o Paulo Research Foundation (FAPESP) based on the USP Ribeir\u00e3o Preto Medical School (FMRP).In the article, entitled SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology, the group led by professor Fernando de Queiroz Cunha showed that an immunological mechanism known as a neutrophil extracellular trap (NET) is involved in the exacerbated inflammatory response that affects patients with the severe form of COVID-19. The discovery paves the way to new therapeutic approaches, including the repositioning of a drug used nowadays against cystic fibrosis (read more at: agencia.fapesp.br\/33435\/).The article was also included in another special collection released by the journal entitled \u201cCOVID-19: from basic science to therapeutics\u201c, which gathers the latest discoveries about the physiopathology of COVID-19, therapeutic targets, and neutralizing antibodies.\u201cThe fact that our work is featured in two different fascicles of a highly reputable journal in the biomedical field is an unequivocal demonstration of the quality of the science that we do at the Ribeir\u00e3o Preto campus of USP \u2013 in particular at the CRID, which is funded by FAPESP. The quality of the work is a consequence of the scientific competence associated with the dedication of all members of the task force involved in investigating the immunopathology of COVID-19 at FMRP-USP\u201d, states Cunha.The collection dedicated to COVID-19 also brings another study developed by scientists connected to the CRID: Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.The work, led by professor Dario Zamboni, describes the participation of an immunological mechanism known as inflammasome in the activation of the inflammatory process, which may cause damage to various organs and even lead to death patients with the severe form of COVID-19 (read more at: agencia.fapesp.br\/34680\/).This text was originally published by Ag\u00eancia FAPESP according to Creative Commons license CC-BY-NC-ND. 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